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Göteborgs universitets publikationer

Small calibre biosynthetic bacterial cellulose blood vessels: 13-months patency in a sheep model.

Författare och institution:
Carl Johan Malm (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Bo Risberg (Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning, Avdelningen för kirurgi); Aase Bodin (Institutionen för kemi- och bioteknik, Polymerteknologi, Chalmers); Henrik Bäckdahl (Institutionen för kemi- och bioteknik, Chalmers); Bengt R Johansson (Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi); Paul Gatenholm (Institutionen för kemi- och bioteknik, Polymerteknologi, Chalmers); Anders Jeppsson (Institutionen för medicin, avdelningen för molekylär och klinisk medicin)
Publicerad i:
Scandinavian cardiovascular journal : SCJ, 46 ( 1 ) s. 57-62
ISSN:
1651-2006
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2012
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Abstract Objectives. Many patients in need of bypass surgery lack graft material and current synthetic alternatives have poor performance. A 4 mm vascular graft composed of bacterial cellulose (BC) was developed and tested in pilot study in a large animal model. Design. BC is a biopolymer made by the bacteria acetobacter xylinum. BC grafts (n = 16) with 4 cm length and 4 mm internal diameter were implanted bilaterally in the carotid arteries of eight sheep. No long-term antithrombotic therapy was administered. Patency was assessed with ultrasound. Histology, immunohistochemistry, and electron microscopy were performed after explantation. Results. Fifty percent of the grafts occluded within two weeks. One animal died with patent grafts after 14 days. In the three remaining animals 5/6 grafts were patent after nine months. Two animals were followed 13 months after implantation with 3/4 grafts patent at explantation. All patent grafts had confluent endothelial-like cells. Conclusions. Biosynthetic small calibre vascular grafts made from BC can be patent for up to 13 months in sheep carotid arteries. BC is a potential material for small calibre grafts but patency in animal models needs to be improved before clinical studies can be planned.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Kirurgi
Nyckelord:
bacterial cellulose; graft; patency
Postens nummer:
149605
Posten skapad:
2011-12-06 13:00
Posten ändrad:
2016-07-15 10:48

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