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Physical training after percutaneous coronary intervention in patients with stable angina: effects on working capacity, metabolism, and markers of inflammation

Författare och institution:
Marco Astengo (-); Asa Dahl (-); Thomas Karlsson (Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin); Lillemor Mattsson Hultén (Wallenberglaboratoriet); Olov Wiklund (Wallenberglaboratoriet); Bertil Wennerblom (-)
Publicerad i:
European Journal of Cardiovascular Prevention & Rehabilitation, 17 ( 3 ) s. 349-354
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Objective Physical activity is effective in primary and secondary prevention of cardiovascular disease. In this study, we tested the hypothesis that exercise training improves glucose and lipid metabolism, the inflammatory/anti-inflammatory balance, and the outcome of elective percutaneous coronary intervention (PCI) in patients with stable coronary disease. Methods Sixty-two patients scheduled to undergo PCI for stable angina were randomized to intensive physical activity (n = 33) consisting of home-based exercise on a bicycle ergometer or maintain their usual sedentary life (n = 29). The training program started 2 months before PCI and terminated 6 months afterwards. Clinical examination, blood sampling (fasting glucose, glycated hemoglobin, lipid profile, apolipoprotein B, apolipoprotein A1, C-reactive protein, serum amyloid A, interleukin-6, interleukin-8, and interleukin-10), and maximal exercise tests were performed at inclusion, 1 week before PCI, and 3 and 6 months afterwards. Results Fifty-six patients [28 per group, 45 men, mean age 63 (SD 7.8) years] completed the follow-up. According to self-reports, patients in the training group exercised more often and longer [4.9 (SD 1.1) vs. 0.6 (SD 1.3) days/week, 36 (SD 12) vs. 15 (SD 31) min/session, P <0.0001]. Improvement in maximal exercise capacity was significantly better in the training group [27 (SD 27) vs. 9 (SD 27)W, P = 0.02]. Exercise had no significant effects on glucose and lipid metabolism, plasma cytokines, or acute-phase reactants. Conclusion A home-based training program significantly improved maximal exercise capacity but did not affect glucose or lipid metabolism or markers of inflammation. Eur J Cardiovasc Prev Rehabil 17:349-354 © 2010 The European Society of Cardiology
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
c-reactive protein, chronic heart-failure, artery-disease, cardiovascular events, aerobic exercise, skeletal-muscle, follow-up, risk, angioplasty, association
Postens nummer:
Posten skapad:
2011-04-18 12:03
Posten ändrad:
2011-12-06 14:02

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