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Göteborgs universitets publikationer

Nocturnal application of transdermal estradiol patches produces levels of estradiol that mimic those seen at the onset of spontaneous puberty in girls.

Författare och institution:
Carina Ankarberg-Lindgren (Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik); M Elfving (-); Kerstin Albertsson-Wikland (Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik); Ensio Norjavaara (Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik)
Publicerad i:
The Journal of clinical endocrinology and metabolism, 86 ( 7 ) s. 3039-44
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The objective of pubertal induction in children with hypogonadism is to mimic spontaneous puberty in terms of physical and psychological development. In a clinical observation study, we induced puberty in 15 girls with hyper- or hypogonadotropic hypogonadism using low doses of transdermal estradiol patches attached only during the night and compared the estradiol concentrations obtained with those in healthy girls. Pubertal induction was started between the ages of 12.3 and 18.1 yr. A transdermal matrix patch of 17beta-estradiol (25 microg/24 h; Evorel, Janssen Pharmaceuticals-Cilag) was cut into pieces corresponding to 3.1, 4.2, or 6.2 microg/24 h initially and attached to the buttock. After 4-14 months, the dose was increased gradually. Serum 17beta-estradiol concentrations were measured every 2 h by RIA (detection limit, 6.0 pmol/L; 1.6 pg/mL). The results show that it is possible to mimic the spontaneous levels as well as the diurnal pattern of serum 17beta-estradiol in early puberty, by cutting a transdermal 17beta-estradiol matrix patch and attaching a part of it, corresponding to 0.08-0.12 microg estradiol/kg BW, to the buttock nocturnally. In most of the girls, breast development occurred within 3-6 months of the start of treatment.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Administration, Cutaneous, Adolescent, Breast, growth & development, Child, Circadian Rhythm, Estradiol, administration & dosage, blood, Female, Humans, Hypogonadism, drug therapy, Linear Models, Puberty, blood
Postens nummer:
Posten skapad:
2011-02-01 10:52
Posten ändrad:
2011-02-01 13:01

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