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Göteborgs universitets publikationer

Decreased exhaled nitric oxide (FENO) in obese with asthma symptoms: Data from the population study INTERGENE/ADONIX

Författare och institution:
Christina Berg (Institutionen för kost- och idrottsvetenskap); Dag Thelle (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Annika Rosengren (Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin); Lauren Lissner (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Anna-Carin Olin (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Kjell Torén (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa)
Publicerad i:
Chest, 139 ( 5 ) s. 1109-1116
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Abstract BACKGROUND: Several studies have demonstrated an association between obesity and asthma. However, it is uncertain if fraction of exhaled nitric oxide (FENO), which is used as a marker of airway inflammation, and atopy are associated with BMI. The aim was to examine if obese with asthma symptoms have a different phenotype of asthma than non-obese as indicated by FENO. METHODS: The subjects (n=2187) consist of women and men, aged 25-74, living in Gothenburg, Sweden, participating in the randomly selected INTERGENE study cohort. Measurements include anthropometric measures, bioelectric impedance, FENO, pulmonary function, blood samples for IgE and questionnaires including items on respiratory symptoms. Obesity was defined as BMI≥30 kg/m(2). In this cross-sectional analysis, general linear models were used to analyse how FENO was associated with anthropometry, body composition, wheezing and atopy. RESULTS: In non-obese subjects, wheezing was associated with raised FENO and atopy, whereas, in contrast, obese with wheezing had lower FENO than obese without wheezing (16.1 v.s. 19.1 ppb, p<0.01). The prevalence of atopy was similar in both those sub-groups (25.0 v.s. 20.7%, p=0.4). Similarly, in 395 subjects (19%) who reported wheezing, FENO was negatively associated with BMI, waist-hip ratio and percentage of body fat, while no significant relationships were observed in those without respiratory symptoms. CONCLUSIONS: Wheezing was significantly associated with reduced FENO in obese subjects, whereas there was a positive association between wheezing and FENO among the non-obese, indicating a possible difference in asthma phenotype, based on body weight.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Hälsovetenskaper ->
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ->
Folkhälsomedicinska forskningsområden
Adult, Aged, Asthma, complications, metabolism, Cohort Studies, Exhalation, Female, Humans, Male, Middle Aged, Nitric Oxide, metabolism, Obesity, complications, metabolism
Postens nummer:
Posten skapad:
2011-01-17 14:32
Posten ändrad:
2012-05-18 11:13

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