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Göteborgs universitets publikationer

Information processing deficits and nitric oxide signalling in the phencyclidine model of schizophrenia.

Författare och institution:
Erik Pålsson (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi); John Lowry (-); Daniel Klamer (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi)
Publicerad i:
Psychopharmacology, 212 ( 4 ) s. 643-651
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
RATIONALE: Schizophrenia-like cognitive deficits induced by phencyclidine (PCP), a drug commonly used to model schizophrenia in experimental animals, are attenuated by nitric oxide (NO) synthase inhibitors. Furthermore, PCP increases NO levels and sGC/cGMP signalling in the prefrontal cortex in rodents. Hence, a cortical NO/sGC/cGMP signalling pathway may constitute a target for novel pharmacological therapies in schizophrenia. OBJECTIVES: The objective of this study was to further investigate the role of NO signalling for a PCP-induced deficit in pre-attentive information processing. MATERIALS AND METHODS: Male Sprague-Dawley rats were surgically implanted with NO-selective amperometric microsensors aimed at the prefrontal cortex, ventral hippocampus or nucleus accumbens, and NO levels and prepulse inhibition (PPI) were simultaneously assessed. RESULTS: PCP treatment increased NO levels in the prefrontal cortex and ventral hippocampus, but not in the nucleus accumbens. The increase in NO levels was not temporally correlated to the deficit in PPI induced by PCP. Furthermore, pretreatment with the neuronal NO synthase inhibitor N-propyl-L-arginine dose-dependently attenuated both the increase in prefrontal cortex NO levels and the deficit in PPI. CONCLUSIONS: These findings support a demonstrated role of NO in the behavioural and neurochemical effects of PCP. Furthermore, this effect is brain region-specific and mainly involves the neuronal isoform of NOS. However, a temporal correlation between a PCP-induced disruption of PPI and an increase in prefrontal cortex NO levels was not demonstrated, suggesting that the interaction between PCP and the NO system is more complex than previously thought.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Farmakologi och toxikologi ->
Prepulse inhibition, Rat, Nitric oxide, Schizophrenia, Voltammetry, Phencyclidine, Prefrontal cortex, Nitric oxide synthase, NMDA receptor
Postens nummer:
Posten skapad:
2011-01-13 14:45
Posten ändrad:
2012-01-10 09:43

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