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Göteborgs universitets publikationer

Self-reported sleep apnoea and mortality in patients from the Swedish Obese Subjects study

Författare och institution:
N.S. Marshall (-); Lotta Delling (Institutionen för medicin); Ronald R Grunstein (-); Markku Peltonen (-); Carl David Sjöström (Institutionen för medicin); Kristjan Karason (Institutionen för medicin); Lena M S Carlsson (Institutionen för medicin); Jan A Hedner (-); Kaj Stenlöf (Institutionen för medicin); Lars Sjöström (Institutionen för medicin)
Publicerad i:
European Respiratory Journal, 38 ( 6 ) s. 1349-1354
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Sleep apnoea is associated with increased mortality in sleep clinic and community population groups. It is unclear whether a clinical report of sleep apnoea results in additional mortality risk in patients with severe obesity. The Swedish Obese Subjects (SOS) study is a nonrandomised controlled trial of bariatric surgery versus conventional treatment for the treatment of severe obesity and its complications (mean±sd body mass index 41±5 kg·m−2). The presence or absence of sleep apnoea (witnessed pauses in breathing) was determined by self-reporting at baseline in 3,953 patients who were observed for 54,236 person-yrs (mean 13.5 maximum 21.0 yrs). Sleep apnoea was reported by 934 (23.6%) patients at baseline and was a significant univariate predictor of mortality (hazard ratio (95% CI) 1.74 (1.40–2.18)). In a range of multivariate models of mortality risk, controlling for ≤16 other potential confounders and established mortality risk factors, sleep apnoea remained a significant prognostic factor (fully adjusted model 1.29 (1.01–1.65)). Self-reported sleep apnoea is an independent prognostic marker of all-cause mortality in obese patients.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Lungmedicin och allergi
Mortality, obesity, sleep apnoea
Postens nummer:
Posten skapad:
2011-01-10 10:57
Posten ändrad:
2012-05-15 15:27

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