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Göteborgs universitets publikationer

Interleukin-17-producing T-helper cells and related cytokines in human airways exposed to endotoxin.

Författare och institution:
Pernilla Glader (Institutionen för medicin, avdelningen för invärtesmedicin); Margaretha E. Smith (Institutionen för medicin, avdelningen för invärtesmedicin); Carina Malmhäll (Krefting Research Centre); Barbro Balder (Institutionen för medicin, avdelningen för invärtesmedicin); Margareta Sjöstrand (Krefting Research Centre); Ingemar Qvarfordt (Institutionen för medicin, avdelningen för invärtesmedicin); Anders Lindén (Institutionen för medicin, avdelningen för invärtesmedicin)
Publicerad i:
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, 36 ( 5 ) s. 1155-64
ISSN:
1399-3003
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2010
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Previous studies on mouse models have indicated that interleukin (IL)-17 and IL-17-producing T-helper (Th) cells are important for pulmonary host defence against Gram-negative bacteria. Human correlates to these findings have not yet been demonstrated. The aim of the present study was to determine whether or not IL-17-producing Th cells are present and whether IL-17 and other Th17-associated cytokines are involved in the immunological response to endotoxin in human airways. Segmental exposure to endotoxin and contralateral exposure to vehicle were performed in the lungs of healthy volunteers, with subsequent bronchoalveolar lavage 12 or 24 h after exposure to study local changes in cytokines and inflammatory cells. Endotoxin exposure increased concentrations of IL-17, IL-22 and their downstream effector molecules, human β-defensin-2 and IL-8/CXC chemokine ligand 8, in bronchoalveolar lavage fluid. Th cells with the capacity to produce IL-17 were found among the bronchoalveolar lavage cells, and expression of IL-17 mRNA correlated with expression of the transcription factor, retinoic-acid-receptor-related orphan receptor C variant 2. Moreover, endotoxin increased the numbers of neutrophils, macrophages and IL-17-producing T-cells, as well as the concentration of the Th17-regulating cytokines, IL-21 and IL-23. In conclusion, IL-17-producing Th cells are present, and IL-17, as well as other Th17-associated cytokines, is involved in the immunological response to endotoxin in human airways.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Dermatologi och venereologi
Postens nummer:
131366
Posten skapad:
2010-12-20 11:50
Posten ändrad:
2016-08-30 14:03

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