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Göteborgs universitets publikationer

Role of mucin Lewis status in resistance to Helicobacter pylori infection in pediatric patients.

Författare och institution:
Sara K. Lindén (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); Cristina Semino-Mora (-); Hui Liu (-); James Rick (-); Andre Dubois (-)
Publicerad i:
Helicobacter, 15 ( 4 ) s. 251-8
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
BACKGROUND: Helicobacter pylori causes gastritis, peptic ulcer and is a risk factor for adenocarcinoma and lymphoma of the stomach. Gastric mucins, carrying highly diverse carbohydrate structures, present functional binding sites for H. pylori and may play a role in pathogenesis. However, little information is available regarding gastric mucin in children with and without stomach diseases. MATERIALS AND METHODS: Expression of mucins and glycosylation was studied by immunohistochemistry on gastric biopsies from 51 children with and without H. pylori infection and/or peptic ulcer disease. RESULTS: In all children, MUC5AC was present in the surface epithelium and MUC6 in the glands. No MUC6 in the surface epithelium or MUC2 was detected in any section. The Le(b) and Le(a) blood group antigens were present in the surface epithelium of 80% and 29% of children, respectively. H. pylori load was higher in Le(b) negative children than in Le(b) positive individuals (mean +/- SEM 17.8 +/- 3.5 vs 10.8 +/- 1.5; p < 0.05), but there was no correlation between Le(a) or Le(b) status and gastritis, nodularity, and gastric or duodenal ulcer (DU). Expression of sialyl-Le(x) was associated with H. pylori infection, and DU. CONCLUSIONS: Mucin expression and glycosylation is similar in children and adults. However, in contrast to adults, pediatric H. pylori infection is not accompanied by aberrant expression of MUC6 or MUC2. Furthermore, the lower H. pylori density in Le(b) positive children indicates that H. pylori is suppressed in the presence of gastric mucins decorated with Le(b), the binding site of the H. pylori BabA adhesin.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
Adolescent, Child, Child, Preschool, Gastric Mucins, genetics, immunology, Helicobacter Infections, genetics, immunology, microbiology, Helicobacter pylori, genetics, physiology, Humans, Immunity, Innate, Lewis Blood-Group System, genetics, immunology, Male
Postens nummer:
Posten skapad:
2010-12-13 12:51
Posten ändrad:
2011-01-07 09:34

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