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Göteborgs universitets publikationer

Urotensin II receptor antagonism does not improve renal hemodynamics or function in rats with endotoxin-induced acute kidney injury.

Författare och institution:
Nicoletta Nitescu (Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi); Elisabeth Grimberg (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Gregor Guron (Institutionen för medicin, avdelningen för molekylär och klinisk medicin)
Publicerad i:
Clinical and experimental pharmacology & physiology, 37 ( 12 ) s. 1170-1175
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
1. Urotensin II (U-II) is a vasoactive peptide that influences renal hemodynamics and kidney function. The aim was to examine the effects of the selective U-II receptor antagonist urantide, on renal hemodynamics, oxygenation and function in endotoxemic rats. 2. Endotoxemia was induced in Sprague-Dawley rats by an intraperitoneal dose of lipopolysaccharide (LPS; E Coli O127:B8, 7.5 mg/kg). At 16 h after endotoxin administration, renal clearance experiments were performed in thiobutabarbital anesthetized rats. Groups (1) sham-saline, (2) sham-urantide, (3) LPS-saline and (4) LPS-urantide, received isotonic saline, or urantide (0.2 mg/kg bolus intravenously, followed by an infusion of 1.2 mg/kg/h throughout), after baseline measurements. Kidney function, renal blood flow (RBF), and cortical and outer medullary perfusion (laser-Doppler flowmetry) and oxygen tension (Clark-type microelectrodes) were analyzed during 2 h of drug administration. 3. At baseline, endotoxemic rats showed approximate 50% reductions in glomerular filtration rate (GFR) and RBF (p<0.05), a decline in cortical and outer medullary perfusion and pO(2) (p<0.05), and a significant increase in mean arterial pressure (MAP; p<0.05), compared to saline-injected controls. In sham animals, urantide in a dose that did not significantly influence MAP or RBF, increased GFR (p<0.05 time x treatment interaction) and filtration fraction (p<0.05 treatment effect). However, urantide had no statistically significant effects on any of the investigated variables in endotoxemic rats. 4. These findings indicate that U-II, via the UT receptor, does not contribute to abnormalities in renal hemodynamics and function in endotoxemic rats.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
acute kidney injury; endotoxin; renal blood flow; sepsis; urantide; urotensin-II
Postens nummer:
Posten skapad:
2010-10-21 13:54
Posten ändrad:
2011-11-24 11:55

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