transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré

Författare och institution:
Natalia Mossberg (Institutionen för neurovetenskap och fysiologi); Oluf Andersen (Institutionen för neurovetenskap och fysiologi); Magnus Nordin (Institutionen för neurovetenskap och fysiologi); Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik, Chalmers/GU); Åke Svedhem (Institutionen för biomedicin); Tomas Bergström (Institutionen för biomedicin); Kristoffer Hellstrand (Institutionen för biomedicin); Charlotta Movitz (Institutionen för biomedicin)
Publicerad i:
Journal of Inflammation, 7 s. Art nr. 40
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Background: The recurrent Guillain-Barré syndrome (RGBS) is characterized by at least two GBS episodes with intervening remission. In a previous study of monophasic GBS, we reported that the magnitude of oxygen radical production ("respiratory burst”) in peripheral blood leukocytes was inversely correlated to disease severity. The present study sought to establish a similar correlation in patients with RGBS. Methods: Oxygen radical production in leukocytes was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val- Met-NH2 (WKYMVM), or phorbol myristate acetate (PMA) and assessed by quantifying superoxide anion formed by the leukocyte NADPH oxidase. Results: Disease severity, assessed using the MRC score, was negatively correlated to superoxide anion production triggered by fMLF or WKYMVM (p = 0.001 and 0.002, respectively; n = 10). Superoxide anion production also was significantly lower in RGBS patients with incomplete recovery after stimulation with fMLF (p = 0.004) or WKYMVM (p = 0.003). Conclusion: We conclude that a lower respiratory burst in leukocytes is strongly associated with a severe course of RGBS
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
oxygen radical production, RGBS, severity
Postens nummer:
Posten skapad:
2010-08-20 15:06
Posten ändrad:
2016-06-29 13:58

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007