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Göteborgs universitets publikationer

Low serum levels of dehydroepiandrosterone sulfate predict all-cause and cardiovascular mortality in elderly Swedish men.

Författare och institution:
Claes Ohlsson (Institutionen för medicin, avdelningen för invärtesmedicin & Centre for Bone and Arthritis Research); Fernand Labrie (-); Elizabeth Barrett-Connor (-); Magnus K Karlsson (-); Östen Ljunggren (-); Liesbeth Vandenput (Institutionen för medicin, avdelningen för invärtesmedicin); Dan Mellström (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Åsa Tivesten (Institutionen för medicin, avdelningen för invärtesmedicin & Wallenberglaboratoriet)
Publicerad i:
The journal of clinical endocrinology and metabolism, 95 ( 9 ) s. 4406-14
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Context: The age-related decline in dehydroepiandrosterone (DHEA) levels is thought to be of importance for general and vascular aging. However, data on the association between DHEA and mortality are conflicting. Objectives: We tested the hypothesis that low serum DHEA and DHEA sulfate (DHEA-S) levels predict all-cause and cardiovascular disease (CVD) death in elderly men. Design, Setting, and Participants: We used gas/liquid chromatography-mass spectrometry to analyze baseline levels of DHEA and DHEA-S in the prospective population-based MrOS Sweden study (2644 men, aged 69-81 yr). Mortality data were obtained from central registers and analyzed using Cox proportional hazards regressions. Main Outcome Measures: All-cause and CVD mortality by serum DHEA(-S) levels. Results: During a mean 4.5-yr follow-up, 328 deaths occurred. Low levels of DHEA-S (quartile 1 vs. quartiles 2-4), predicted death from all causes [hazard ratio (HR) 1.54, 95% confidence interval (CI) 1.21-1.96; adjusted for traditional cardiovascular risk factors], from CVD (n = 123 deaths; HR 1.61, 95% CI 1.10-2.37) and ischemic heart disease (n = 73; HR 1.67, 95% CI 1.02-2.74) but not cancer. Analyses with DHEA gave similar results. The association between low DHEA-S and CVD death remained after adjustment for C-reactive protein and circulating estradiol and testosterone levels. When stratified by the median age of 75.4 yr, the mortality prediction by low DHEA-S was more pronounced among younger (age adjusted HR for CVD death 2.64, 95% CI 1.37-5.09) than older men (HR 1.30, 95% CI 0.83-2.04). Conclusions: Low serum levels of DHEA(-S) predict death from all causes, CVD, and ischemic heart disease in older men.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Endokrinologi och diabetes ->
Postens nummer:
Posten skapad:
2010-08-09 20:42
Posten ändrad:
2011-01-18 12:18

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