transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Low levels of exhaled nitric oxide are associated with impaired lung function in cystic fibrosis.

Författare och institution:
Christina Keen (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för pediatrik); Per M. Gustafsson (-); Anders Lindblad (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för pediatrik); Göran Wennergren (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för pediatrik); Anna-Carin Olin (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa)
Publicerad i:
Pediatric pulmonology, 45 ( 3 ) s. 241-8
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Fraction of exhaled nitric oxide (FENO) is often reduced in cystic fibrosis (CF). FENO at different expiratory flows can provide an indication of the site of nitric oxide production. The aim of this study was to examine whether NO parameters are related to overall (FEV(1)) or peripheral (lung clearance index, LCI, measured by multiple breath SF(6) washout) airway function and systemic inflammation in CF. Secondary aim was to compare alveolar NO and bronchial NO flux calculated by two different mathematical models, a linear and a nonlinear method. Thirty-five healthy and 45 CF children were recruited. FENO at 50 ml/sec (FENO(50)) and bronchial NO flux were lower in CF than controls, 9.5 (2.7-38.8) (median (range)) versus 12.4 (5.2-40.1) ppb, P = 0.029, and 391 (97-1772) versus 578 (123-1993) (pl/sec), P = 0.036, respectively. No difference in alveolar NO was shown. The nonlinear method resulted in lower alveolar NO and higher bronchial flux, than the linear method, but the result was closely correlated in both groups. LCI was higher in CF than controls, 8.4 (6.5-12.9) versus 5.9 (5.1-7.8), P < 0.001. FENO(50) was negatively correlated with LCI (r = -0.43; P = 0.003) and positively correlated with FEV(1) (r = 0.42, P = 0.004) in CF. Alveolar NO correlated negatively with inflammatory markers: orosomucoid (r = -0.42, P = 0.005), platelets (r = -0.50, P < 0.001) and white blood cell count (r = -0.48, P = 0.001). In conclusion, FENO(50) and bronchial NO flux are reduced in young CF subjects and low FENO(50) is associated with overall and small airway obstruction. NO parameters derived from the different models were closely related but the values differed slightly.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Immunologi inom det medicinska området ->
Klinisk medicin ->
Dermatologi och venereologi
Annan samhällsvetenskap ->
Övrig annan samhällsvetenskap ->
Adolescent, Biological Markers, blood, Breath Tests, Bronchi, metabolism, Case-Control Studies, Child, Cross-Sectional Studies, Cystic Fibrosis, blood, physiopathology, Female, Forced Expiratory Volume, Humans, Leukocyte Count, Male, Models, Statistical, Nitric Oxide, analysis, metabolism, Orosomucoid, analysis, Platelet Count, Pulmonary Alveoli, metabolism, Sulfur Hexafluoride, diagnostic use, Total Lung Capacity
Postens nummer:
Posten skapad:
2010-06-07 10:21
Posten ändrad:
2011-07-06 14:34

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007