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Mucosal immunization of piglets with purified F18 fimbriae does not protect against F18+ Escherichia coli infection.

Författare och institution:
F Verdonck (-); P Tiels (-); K van Gog (-); B M Goddeeris (-); Nils Y Lycke (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); J Clements (-); E Cox (-)
Publicerad i:
Veterinary immunology and immunopathology, 120 ( 3-4 ) s. 69-79
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Post-weaning diarrhoea and oedema disease in weaned piglets are caused by infection with F4+ or F18+ Escherichia coli strains. There is no commercial vaccine available, but it is shown that oral immunization of weaned piglets with purified F4 fimbriae induces a protective mucosal immune response. In the present study, piglets were orally and nasally immunized with purified F18 fimbriae in the presence of the mucosal adjuvant LT(R192G) or CTA1-DD, respectively. This immunization could not lead to protection against F18+ E. coli infection. The induced F18-specific immune response was directed towards the major subunit FedA and weakly towards the adhesive subunit FedF. The results of these experiments demonstrate that it is difficult to induce protective immunity against F18+ E. coli using the whole fimbriae due to the low response against the adhesin.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
Administration, Intranasal, Administration, Oral, Animals, Antibodies, Bacterial, blood, Bacterial Vaccines, administration & dosage, immunology, Drug Administration Routes, Escherichia coli, genetics, isolation & purification, Escherichia coli Infections, prevention & control, veterinary, Escherichia coli Proteins, genetics, immunology, isolation & purification, Feces, microbiology, Fimbriae Proteins, genetics, immunology, isolation & purification, Immunity, Mucosal, immunology, Immunoglobulin G, blood, Immunoglobulin M, blood, Swine, Swine Diseases, immunology, prevention & control, Time Factors, Treatment Failure
Postens nummer:
Posten skapad:
2010-05-06 15:15
Posten ändrad:
2010-11-11 12:35

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