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A low serum leptin level at baseline and a large early decline in leptin predict a large 1-year weight reduction in energy-restricted obese humans.

Författare och institution:
Jarl S Torgerson (Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism); Björn Carlsson (Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism); Kaj Stenlöf (Institutionen för invärtesmedicin); Lena M S Carlsson (Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism); E Bringman (-); Lars Sjöström (Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism)
Publicerad i:
The Journal of clinical endocrinology and metabolism, 84 ( 11 ) s. 4197-203
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The difficulty in maintaining weight loss during obesity treatment may be caused by a counteracting neuroendocrine response. It has been proposed that leptin could be a regulator of this response. We examined the relations between leptin levels during an initial very low calorie diet, other simultaneous endocrine changes, and the 1-yr weight reduction. Sixty-nine obese (24 men and 45 women) were treated with very low calorie diet for 16 weeks, followed by a hypocaloric diet for 32 weeks. Serum levels of leptin, insulin, cortisol, and thyroid hormones were measured at weeks 0, 8, and 18. The relative weight reductions after 18 and 48 weeks were 20.1% and 14.4% in men and 15.4% and 11.8% in women. Low initial leptin levels and large declines in serum leptin were associated with a large 1-yr weight loss in both genders. Leptin levels (baseline or changes) were not independently associated with the changes in insulin, cortisol, or thyroid hormones. Our results may indicate that leptin by itself could be of minor importance for the neuroendocrine response to severe caloric restriction in humans.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Endokrinologi och diabetes ->
Adolescent, Adult, Body Mass Index, Diet, Reducing, Energy Intake, Female, Humans, Hydrocortisone, blood, Insulin, blood, Leptin, metabolism, Male, Middle Aged, Obesity, blood, diet therapy, Thyrotropin, blood, Thyroxine, blood, Triiodothyronine, blood, Weight Loss
Postens nummer:
Posten skapad:
2010-04-08 13:49
Posten ändrad:
2011-01-20 10:00

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