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Göteborgs universitets publikationer

Health-related quality of life in patients undergoing allogeneic stem cell

Författare och institution:
Inger Andersson (Institutionen för vårdvetenskap och hälsa); Karin Ahlberg (Institutionen för vårdvetenskap och hälsa); Dick Stockelberg (-); Mats Brune (-); Lars-Olof Persson (Institutionen för vårdvetenskap och hälsa)
Publicerad i:
Cancer Nursing, 32 ( 4 ) s. 325-34.
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The aim of this prospective study was to describe health-related quality of life (HRQOL) in patients during the first year after stem cell transplantation (SCT) who were undergoing reduced intensive conditioning (RIC) compared with patients undergoing myeloablative conditioning (MAC). Fifty-seven patients (25 for MAC and 32 for RIC) were enrolled in the study. HRQOL was assessed at 6 occasions during the first year after SCT using European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and the 19-item treatment-specific module High-Dose Chemotherapy. Both groups reported most symptoms and worst functioning 1 month after SCT, but there were substantial differences. The MAC group deteriorated considerably in 20 symptom scales compared with 8 in the RIC group (score differences <10; P values ranged from .001 to .05). Dry mouth, sore mouth, appetite loss, and change of taste were among the most frequent symptoms in both groups. Thereafter, the functioning improved and the symptom scores decreased and returned to baseline in both groups, except dry mouth, which remained a worse problem for the MAC group. Overall, the RIC group regained health and QOL faster than the MAC group did. However, there were no significant differences in global QOL between the groups 1 year after SCT.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Hälsovetenskaper ->
Allogeneic stem cell transplantation, EORTC QLQ-C30, HDC-19, Health-related quality of life, Myeloablative conditioning (MAC), Nursing, Reduced intensity conditioning (RIC), Symptoms
Postens nummer:
Posten skapad:
2010-02-25 10:20
Posten ändrad:
2012-06-20 10:53

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