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Göteborgs universitets publikationer

Estramustine induces disorganization of microtubules, perinuclear retraction of vimentin and endoplasmatic reticulum, and inhibits cell migration.

Författare och institution:
M Rutberg (Zoologiska institutionen); Margareta Wallin (Zoologiska institutionen)
Publicerad i:
Acta histochemica, 95 ( 2 ) s. 155-67
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The effects of the mitotic inhibitor estramustine on the cytoskeleton of DU 145 and AG 1518 cells were studied. Estramustine caused a partial disassembly of microtubules and withdrawal of microtubules from the cell periphery, disorganized microtubules and delayed regrowth of disassembled microtubules. It also induced a spheroid cellular morphology and affected cellular adhesion and survival. Sometimes microtubules seemed to be organized from several microtubule-organizing centers. The cytoskeleton-dependent cell migration was inhibited in the presence of estramustine and the microtubule-interacting vimentin and endoplasmatic reticulum retracted to the perinuclear area. Our results show that not only a complete disassembly of microtubules, but also disturbances of the microtubule network can have dramatic effects on microtubule-dependent processes and localization of cellular organelles. These effects could be of importance in the treatment of prostatic carcinoma with estramustine.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Biologiska vetenskaper ->
Biokemi och molekylärbiologi ->
Cell- och molekylärbiologi
Cell Adhesion, drug effects, Cell Line, Cell Movement, drug effects, Cell Nucleus, drug effects, metabolism, ultrastructure, Cell Survival, drug effects, Endoplasmic Reticulum, drug effects, ultrastructure, Estramustine, administration & dosage, pharmacology, Humans, Immunohistochemistry, Microscopy, Electron, Scanning, Microtubules, drug effects, ultrastructure, Vimentin, immunology, metabolism, Vinblastine, pharmacology
Postens nummer:
Posten skapad:
2010-02-23 13:51

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