transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Melanophores: a model system for neuronal transport and exocytosis?

Författare och institution:
Sara Aspengren (Zoologiska institutionen); Daniel Hedberg (Zoologiska institutionen); Margareta Wallin (Zoologiska institutionen)
Publicerad i:
Journal of neuroscience research, 85 ( 12 ) s. 2591-600
Artikel, forskningsöversikt
Sammanfattning (abstract):
Black pigment cells, melanophores, from lower vertebrates are specialized in bidirectional and coordinated translocation of pigment granules, melanosomes, in the cytoplasm. Melanophores develop from the neuronal crest and are most abundant in the dermal and epidermal layers of the skin, where the intracellular distribution of the pigment significantly influences the color of the animal. The transport of pigment is dependent on an intact cytoskeleton and motor proteins associated with cytoskeletal components. The easily cultured melanophores have proved to be excellent models for organelle transport because the intracellular movements of pigment can be visualized via light microscopy, and the granules move in response to defined chemical signals. The ease of achieving a combination of morphological and functional transport studies is the advantage of the melanophore system, and studies on pigment cells have revealed new components of the transport machinery, including molecular motors, their adapters, and transfer of vesicles to other cells. Many cellular components are transported with a combination of the actin- and microtubule-based transport systems, and, since all eukaryotic organisms rely on functional intracellular transport and an intact cytoskeleton, studies on melanophores are important for many aspects of cell biology, including axonal transport. In this review, we present an overview of the research on the pigment transport system and the potential use of pigment cells as a model system.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Biologiska vetenskaper
Biologiska vetenskaper ->
Biokemi och molekylärbiologi ->
Cell- och molekylärbiologi
Animals, Axonal Transport, physiology, Exocytosis, physiology, Melanophores, metabolism, Models, Biological, Neurons, cytology, physiology
Postens nummer:
Posten skapad:
2010-02-23 13:29
Posten ändrad:
2010-06-19 16:15

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007