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Cognitive Impairment Questionnaire (CIMP-QUEST): reported topographic symptoms in MCI and dementia.

Författare och institution:
Ragnar Åstrand (-); Sindre Rolstad (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Anders Wallin (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi)
Publicerad i:
Acta neurologica Scandinavica, 121 ( 6 ) s. 384-391
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Astrand R, Rolstad S, Wallin A. Cognitive Impairment Questionnaire (CIMP-QUEST): reported topographic symptoms in MCI and dementia. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2007.01312.x. (c) 2009 The Authors Journal compilation (c) 2009 Blackwell Munksgaard. Objective - The Cognitive Impairment Questionnaire (CIMP-QUEST) is an instrument based on information obtained by key informants to identify symptoms of dementia and dementia-like disorders. The questionnaire consists of three subscales reflecting impairment in parietal-temporal (PT), frontal (F) and subcortical (SC) brain regions. The questionnaire includes a memory scale and lists non-cognitive symptoms. The reliability and validity of the questionnaire were examined in 131 patients with mild cognitive impairment (MCI) or mild dementia at a university-based memory unit. Methods/Results - Cronbach alpha for all subscales was calculated at r = 0.90. Factor analysis supported the tri-dimensionality of CIMP-QUEST's brain region-oriented construct. Test-retest reliability for a subgroup of cognitively stable MCI-patients (n = 25) was found to be r = 0.83 (P = 0.0005). The correlation between the score on the cognitive subscales (PT + F + M) and Informant Questionnaire on Cognitive Decline in the Elderly was r = 0.83 (P = 0.0005, n = 123). The memory subscale correlated significantly with episodic memory tests, the PT subscale with visuospatial and language-oriented tests, and the SC and F subscales with tests of attention, psychomotor tempo and executive function. Conclusions - CIMP-QUEST has high reliability and validity, and provides information about cognitive impairment and brain region-oriented symptomatology in patients with MCI and mild dementia.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
brain regional, dementia, informant, MCI, questionnaire, validation
Postens nummer:
Posten skapad:
2010-02-23 09:14
Posten ändrad:
2012-02-06 13:25

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