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Göteborgs universitets publikationer

Renal concentrating capacity in female outpatients with symptomatic urinary tract infection.

Författare och institution:
Birgit Stattin Norinder (-); Torsten Sandberg (Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar); Ragnar Norrby (-)
Publicerad i:
Scandinavian Journal of Urology and Nephrology, 39 ( 6 ) s. 483-7
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
OBJECTIVE: Renal concentrating capacity (RCC) has been used as a tool in the diagnosis of the site of urinary tract infection (UTI). In this study, RCC was measured in women with symptoms of UTI in relation to the clinical picture and the bacterial species isolated. MATERIAL AND METHODS: In 633 outpatients aged > or =18 years with symptoms of UTI, a renal concentration test with desmopressin was performed at baseline. The test was repeated after antibiotic treatment in a subset of patients with osmolality values below the reference levels at entry. The bacterial species were identified and patients were classified as having either pyelonephritis or cystitis. RESULTS: RCC was reduced in patients infected with Escherichia coli or Staphylococcus saprophyticus compared to those who had negative urine cultures and increased after antibiotic treatment. Patients with symptoms of both pyelonephritis and cystitis had reduced RCC: 44/68 (65%) and 205/457 (45%), respectively. CONCLUSIONS: These findings demonstrate a considerable overlap in RCC between patients with pyelonephritis and cystitis, making the osmolality test unreliable for the purpose of diagnosis of the site of UTI.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, therapeutic use, Antidiuretic Agents, diagnostic use, Deamino Arginine Vasopressin, diagnostic use, Female, Follow-Up Studies, Humans, Kidney Concentrating Ability, drug effects, physiology, Middle Aged, Osmolar Concentration, Outpatients, Urinary Tract Infections, drug therapy, physiopathology, urine
Postens nummer:
Posten skapad:
2010-02-19 13:40
Posten ändrad:
2011-01-20 10:00

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