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Göteborgs universitets publikationer

Coupling between serotoninergic and noradrenergic neurones and gamma-motoneurones in the cat.

Författare och institution:
M H Gladden (-); D J Maxwell (-); A Sahal (-); Elzbieta Jankowska (Institutionen för fysiologi och farmakologi)
Publicerad i:
The Journal of physiology, 527 Pt 2 s. 213-23
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Noradrenaline is known to suppress transmission from group II muscle afferents when locally applied to gamma-motoneurones, and serotonin (5-HT) facilitates the transmission. The purpose of this investigation was to search for evidence of monoaminergic innervation of gamma-motoneurones. Eight gamma-motoneurones were labelled with rhodamine-dextran, and 50 micrometer thick sagittal sections of the spinal cord containing them were exposed to antibodies against dopamine beta-hydroxylase (DBH) and 5-HT. All the cells were directly and/or indirectly excited by muscle group II afferents from the muscle they innervated and/or other muscles. Appositions between monoaminergic fibres and the labelled somata and dendrites were located with three-colour confocal laser scanning microscopy by examining series of optical sections at 1 or 0.5 micrometer intervals. DBH and 5-HT varicosities formed appositions with the somata and dendrites of all the gamma-motoneurones. The mean packing densities for 5-HT (1.12 +/- 0.11 appositions per 100 micrometer(2) for somata and 0.91 +/- 0.07 per 100 micrometer(2) for dendrites) were similar to the densities of contacts reported for alpha-motoneurones. Monoaminergic varicosities in apposition to dendrites greatly outnumbered those on the somata. The density of DBH appositions was consistently lower - corresponding means were 53% and 62% of those for 5-HT on the somata and dendrites, respectively. It is concluded from an analysis of the distribution and density of varicosities in apposition to the gamma-motoneurones compared with the density in the immediate surround of the dendrites that there is indeed both a serotoninergic and noradrenergic innervation of gamma-motoneurones.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Animals, Cats, Cell Communication, physiology, Dendrites, physiology, Dextrans, Dopamine beta-Hydroxylase, metabolism, Hindlimb, innervation, Image Processing, Computer-Assisted, Microscopy, Confocal, Motor Neurons, Gamma, physiology, ultrastructure, Nerve Fibers, physiology, Neurons, physiology, ultrastructure, Norepinephrine, physiology, Rhodamines, Serotonin, physiology, Spinal Cord, cytology
Postens nummer:
Posten skapad:
2010-02-03 11:08
Posten ändrad:
2011-01-20 09:59

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