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Göteborgs universitets publikationer

Release of active pharmaceutical ingredients from Indian bulk drug manufacture – environmental fate and effects on antibiotic resistance development, microbial ecosystems and vertebrate physiology

Författare och institution:
D. G. Joakim Larsson (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Jerker Fick (-); Yougesh Schouche (-); Gunnar Carlsson (-); Sara Brosché (Institutionen för växt- och miljövetenskaper); Lina-Maria Gunnarsson (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Thomas Backhaus (Institutionen för växt- och miljövetenskaper); Lars Förlin (Zoologiska institutionen); Malte Hermansson (Institutionen för cell- och molekylärbiologi); Edward R.B. Moore (Institutionen för biomedicin, avdelningen för infektionssjukdomar)
Publicerad i:
2008 Society of Environmental Toxicology and Chemistry, November 16-20, Tampa, USA,
Konferensbidrag, refereegranskat
Sammanfattning (abstract):
Last year, we published a paper showing extraordinary high levels of several drugs in treated effluent from a plant receiving process water from about 90 bulk drug manufacturers from the Hyderabad region in India. Particularly, the levels of various fluoroquinolones (up to 31 mg/L) called for more information on the potential development of antibiotic resistance of exposed bacteria, as well as potential ecological effects on microbial ecosystems. In this study we will present the first characterization of 93 strains of bacteria sampled inside the treatment facility for their sensitivity/resistance to 39 different antibiotics. Furthermore, controlled exposure experiments suggest that the treated effluent affects the functional structure of natural freshwater microbial communities at a dilution of 1:1000. Short to medium-term exposure experiments with frogs and fish demonstrate sublethal effects of the treated effluent at similar dilutions, suggesting that expected environmental effects are not restricted to disturbed microorganism communities. Data on the fate of different pharmaceuticals in a gradient up and downstream from the treatment facility will be presented, as well as levels in drinking water wells in seven nearby villages, showing a transport of drugs via the groundwater. We conclude that the environmental impact of drug production in the Hyderabad region is of great environmental concern. We will also present summary data on the origin of active substances present in pharmaceutical products on the Swedish market, implying an international responsibility for improving the environmental pollution situation related to bulk drug production in India.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Geovetenskap och miljövetenskap ->
Miljövetenskap ->
Miljökemi ->
Pharmaceuticals, Effluent, Toxicity, Water quality
Postens nummer:
Posten skapad:
2010-01-23 04:45
Posten ändrad:
2011-01-20 10:00

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