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Göteborgs universitets publikationer

Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis

Författare och institution:
Martin Berglund (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); James A Thomas (-); Maria Fritsch Fredin (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); Silvia Melgar (-); Elisabeth Hultgren-Hörnquist (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); Olof H. Hultgren (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi)
Publicerad i:
Cellular Immunology, 259 ( 1 ) s. 27-32
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Toll-like receptor (TLR) signaling is important for the induction of pro-inflammatory cytokines and interferon (IFN)-inducible genes in response to bacterial and viral challenge. Interleukin-1 receptor-associated kinase-1 (IRAK-1) is a signaling kinase situated downstream of the adapter protein myeloid differentiation factor 88 (MyD88) in the TLR intracellular signaling cascade and is required for normal signal transduction through this pathway. We investigated the importance of IRAK-1 in intestinal inflammation by using the dextran sulfate sodium (DSS)-colitis model. We show that IRAK-1 deficient mice are protected against systemic signs of inflammation, i.e., weight loss and spleen enlargement compared to wild-type controls irrespective of gender. However, IRAK-1(-/y) males but not IRAK-1(-/-) females display significant protection against colitis and thymic atrophy compared to wild-type mice. Our results indicate a gender specific effect of IRAK-1 in the DSS-induced colitis, an interesting finding since the Irak-1 gene is located on the X-chromosome and several inflammatory diseases have a gender dependent incidence.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Immunologi inom det medicinska området
Animals, Colitis, chemically induced, genetics, pathology, Colon, metabolism, pathology, Dextran Sulfate, toxicity, Female, Interferon-gamma, metabolism, Interleukin-1 Receptor-Associated Kinases, genetics, physiology, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Sex Factors, Thymus Gland, pathology, physiology, X Chromosome, genetics
Postens nummer:
Posten skapad:
2010-01-15 08:57
Posten ändrad:
2011-01-20 09:59

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