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Göteborgs universitets publikationer

Perinatal essential fatty acid deficiency influences body weight and bone parameters in adult male rats.

Författare och institution:
Marina Korotkova (Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik); Claes Ohlsson (Institutionen för invärtesmedicin, Avdelningen för internmedicin); B Gabrielsson (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Lars Åke Hanson (Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi); Birgitta Strandvik (Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik)
Publicerad i:
Biochimica et biophysica acta, 1686 ( 3 ) s. 248-54
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Fetal and postnatal nutrition have long-term effects on the risk for development of diseases late in life in humans and animals. The aim of the present study was to investigate the effect of dietary deficiency of essential fatty acids (EFA) in the perinatal period on later body weight and bone mass. During late gestation and throughout lactation, rats were fed a control or an EFA-deficient (EFAD) diet. At 3 weeks of age the offspring were weaned onto an ordinary chow and followed until adult age. The mean body weight of adult rats receiving the EFAD diet during the perinatal period was significantly increased from 12 weeks of age compared to the controls (P<0.05). Analysis by peripheral quantitative computerized tomography (pQCT) at 44 weeks of age showed that the trabecular volumetric bone mineral density (BMD) of the femur was significantly decreased (P<0.05) but the cortical bone mineral content, cortical area, and cortical thickness were increased (P<0.05) in the EFAD group of rats. The length of the femur was not affected. In conclusion, neonatal EFA deficiency was in adult rats associated with increased body weight and significant changes in both cortical and trabecular bone. The results indicate that regulatory mechanisms related to bone mass seemed to be programmed by EFA in the perinatal period. The nature of this modulation needs to be identified.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Endokrinologi och diabetes ->
Animal Feed, Animals, Body Weight, Bone Development, Bone and Bones, metabolism, Fatty Acids, Essential, blood, deficiency, Insulin-Like Growth Factor I, analysis, Leptin, blood, Male, Rats, Rats, Sprague-Dawley
Postens nummer:
Posten skapad:
2010-01-12 11:16
Posten ändrad:
2010-03-03 14:50

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