transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Increased liver enzymes in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

Författare och institution:
Henrik Falhammar (-); Helena Filipsson (Institutionen för medicin, avdelningen för invärtesmedicin); Gundela Holmdahl (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Per-Olof Janson (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Agneta Nordenskjöld (-); Kerstin Hagenfeldt (-); Marja Thorén (-)
Publicerad i:
Endocrine journal, 56 ( 4 ) s. 601-8
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The aims were assessing liver function tests (LFT) in women with congenital adrenal hyperplasia (CAH) on glucocorticoids. Sixty-one women with genetically verified CAH due to 21-hydroxylase deficiency, aged 18-63 years were compared to 61 controls. Serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT), anthropometry and fat mass (dual energy X-ray absorptiometry) were measured. ALT and GGT were higher in the entire patient group (p=0.01 and 0.002); AST, GGT and ALP in patients > or =30 years (p=0.007-0.045); all LFT in salt-wasting (p<0.001-0.042); GGT in simple virilizing (p=0.008); ALT, GGT and ALP in Null/Null genotype (p=0.018-0.040); ALT and GGT in I2splice genotype (p<0.001 and 0.011). Using a recently proposed cut-off level for ALT (>0.317 microkat/L), 54% of patients vs 23% of controls had elevated levels (p=0.028). In patients, GGT and ALP correlated with waist circumference and with total body and trunk fat (r=0.274-0.406, p=0.001-0.043). However, ALT, GGT and ALP were increased even in non-obese patients (waist circumference < or =88 cm and body mass index <30 kg/m(2)) (p=0.012-0.045) mainly attributed to the patients > or =30 years who also demonstrated elevated insulin levels and HOMA-indices. In conclusion, compared with controls, women with CAH have higher LFT, in particular patients > or =30 years and those with severe forms, probably reflecting a higher lifetime glucocorticoid exposure. LFT were positively correlated to measurements of body fat. These women might have increased frequency of NAFLD. The finding of higher LFT also in non-obese patients suggests that not only central obesity but also glucocorticoids per se may influence.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Adolescent, Adrenal Hyperplasia, Congenital, enzymology, Adult, Alanine Transaminase, blood, Alkaline Phosphatase, blood, Aspartate Aminotransferases, blood, Blood Glucose, metabolism, Female, Humans, Insulin, blood, Liver, enzymology, Liver Function Tests, Middle Aged, Steroid 21-Hydroxylase, Waist Circumference, gamma-Glutamyltransferase, blood
Postens nummer:
Posten skapad:
2010-01-04 16:19

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007