transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Regional distribution of common and dysplastic naevi in relation to melanoma site and sun exposure. A case-control study.

Författare och institution:
Ulrika Stierner (Institutionen för särskilda specialiteter, Avdelningen för onkologi); A Augustsson (Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi); Inger Rosdahl (Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi); M Suurküla (-)
Publicerad i:
Melanoma research, 1 ( 5-6 ) s. 367-75
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The frequency of melanoma (CMM), and of common and dysplastic naevi (CN and DN) in areas of skin chronically, intermittently and rarely exposed to UV light was investigated in 121 melanoma patients (30-50 years) and 310 controls. Both cases and controls had significantly more CN in intermittently exposed areas than in areas chronically or rarely exposed. The ratio of observed to expected number of CMM was also highest in intermittently exposed skin (1.3 compared to 0.8 in chronically exposed and 0.5 in rarely exposed areas). Thus, intermittent UV exposure seems to have the most potent 'naevogenic' as well as carcinogenic effect on melanocytes. Nineteen per cent of controls and 56% of cases had naevi fulfilling the clinical criteria for DN. The distribution pattern of DN was clearly different from that of CN and does not accord with the idea that UV light is a major aetiological factor for DN. The probability of CMM significantly increased with the degree of relative clustering of CN (p less than 0.05) and of DN (p less than 0.01). This co-variation of naevi and CMM over the body surface might be the result of the local insults to the melanocyte system caused by UV light and/or to the fact that naevi are precursor lesions of CMM.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Cancer och onkologi
Adult, Case-Control Studies, Disease Susceptibility, Dysplastic Nevus Syndrome, epidemiology, etiology, Humans, Male, Melanocytes, pathology, radiation effects, Melanoma, epidemiology, etiology, Middle Aged, Neoplasms, Multiple Primary, epidemiology, Neoplasms, Radiation-Induced, epidemiology, Nevus, Pigmented, epidemiology, Precancerous Conditions, epidemiology, Sex Factors, Skin Neoplasms, epidemiology, etiology, Sunlight, adverse effects, Sweden, epidemiology, Ultraviolet Rays, adverse effects
Postens nummer:
Posten skapad:
2009-10-20 13:17
Posten ändrad:
2010-02-15 17:26

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007